Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during progression of epithelial cancer, we used a mouse model with skin-specific overexpression of Snail. Snail transgenic mice spontaneously developed distinct...

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Detalhes bibliográficos
Main Authors: De Craene, B, Denecker, G, Vermassen, P, Taminau, J, Mauch, C, Derore, A, Jonkers, J, Fuchs, E, Berx, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890953/
https://ncbi.nlm.nih.gov/pubmed/24162662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.148
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