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BK channel opening involves side-chain reorientation of multiple deep-pore residues
Three deep-pore locations, L312, A313, and A316, were identified in a scanning mutagenesis study of the BK (Ca(2+)-activated, large-conductance K(+)) channel S6 pore, where single aspartate substitutions led to constitutively open mutant channels (L312D, A313D, and A316D). To understand the mechanis...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890798/ https://ncbi.nlm.nih.gov/pubmed/24367115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321697111 |
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