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Mutation and Cancer: Statistical Study of Retinoblastoma

Based upon observations on 48 cases of retinoblastoma and published reports, the hypothesis is developed that retinoblastoma is a cancer caused by two mutational events. In the dominantly inherited form, one mutation is inherited via the germinal cells and the second occurs in somatic cells. In the...

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Detalhes bibliográficos
Autor principal: Knudson, Alfred G.
Formato: Artigo
Idioma:Inglês
Publicado em: 1971
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC389051/
https://ncbi.nlm.nih.gov/pubmed/5279523
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