Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear if specific hippocampal synapses are parti...

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Main Authors: Wilke, Scott A., Raam, Tara, Antonios, Joseph K., Bushong, Eric A., Koo, Edward H., Ellisman, Mark H., Ghosh, Anirvan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890281/
https://ncbi.nlm.nih.gov/pubmed/24454724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084349
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