Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners

Tumor-initiating cells (TICs) play a central role in tumor development, metastasis, and recurrence. In the present study, we investigated the effect of disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, toward tumor-initiating hepatocellular carcinoma (HCC) cells. DSF treatment suppressed the...

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Bibliographic Details
Main Authors: Chiba, Tetsuhiro, Suzuki, Eiichiro, Yuki, Kaori, Zen, Yoh, Oshima, Motohiko, Miyagi, Satoru, Saraya, Atsunori, Koide, Shuhei, Motoyama, Tenyu, Ogasawara, Sadahisa, Ooka, Yoshihiko, Tawada, Akinobu, Nakatsura, Tetsuya, Hayashi, Takehiro, Yamashita, Taro, Kaneko, Syuichi, Miyazaki, Masaru, Iwama, Atsushi, Yokosuka, Osamu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890271/
https://ncbi.nlm.nih.gov/pubmed/24454751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084807
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