Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer

A causal role of gene amplification in tumorigenesis is well-known, while amplification of DNA regulatory elements as an oncogenic driver remains unclear. In this study, we integrated next-generation sequencing approaches to map distant estrogen response elements (DEREs) that remotely control transc...

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Huvudupphovsmän: Hsu, Pei-Yin, Hsu, Hang-Kai, Lan, Xun, Juan, Liran, Yan, Pearlly S., Labanowska, Jadwiga, Heerema, Nyla, Hsiao, Tzu-Hung, Chiu, Yu-Chiao, Chen, Yidong, Liu, Yunlong, Li, Lang, Li, Rong, Thompson, Ian M., Nephew, Kenneth P., Sharp, Zelton D., Kirma, Nameer B., Jin, Victor X., Huang, Tim H.-M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890247/
https://ncbi.nlm.nih.gov/pubmed/23948299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.07.007
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