Inhibition of Serine Proteases by Arylboronic Acids
Arylboronic acids were found to be strong competitive inhibitors of subtilisin and chymotrypsin. The binding constants are strongly pH dependent and give a Hammett-type plot with a slope of -0.885. The pH dependence, the Hammett plot, and nmr model-system studies indicate that inhibition is due to e...
Na minha lista:
| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1971
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4993411/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.68.2.478 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|