Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion In Vitro Does Not Always Correlate with Attenuation of Virulence

The EspA protein of Mycobacterium tuberculosis is essential for the type VII ESX-1 protein secretion apparatus, which delivers the principal virulence factors ESAT-6 and CFP-10. In this study, site-directed mutagenesis of EspA was performed to elucidate its influence on the ESX-1 system. Replacing T...

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Bibliografiske detaljer
Main Authors: Chen, Jeffrey M., Zhang, Ming, Rybniker, Jan, Basterra, Laetitia, Dhar, Neeraj, Tischler, Anna D., Pojer, Florence, Cole, Stewart T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889621/
https://ncbi.nlm.nih.gov/pubmed/24078612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00967-13
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