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Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

Normal cells secrete heat shock protein 90 alpha (Hsp90α) in response to tissue injury. Tumor cells have managed to constitutively secrete Hsp90α during invasion and metastasis. The sole function of extracellular Hsp90α (eHsp90α) is to promote cell motility, a critical event for both wound healing a...

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Detalhes bibliográficos
Main Authors: Tsen, Fred, Bhatia, Ayesha, O'Brien, Kathryn, Cheng, Chieh-Fang, Chen, Mei, Hay, Nissim, Stiles, Bangyan, Woodley, David T., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889557/
https://ncbi.nlm.nih.gov/pubmed/24126057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00559-13
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