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The Mark Coventry Award: Higher Tissue Concentrations of Vancomycin With Low-dose Intraosseous Regional Versus Systemic Prophylaxis in TKA: A Randomized Trial

BACKGROUND: In response to increasing antibiotic resistance, vancomycin has been proposed as an alternative prophylactic agent in TKA. However, vancomycin requires a prolonged administration time, risks promoting further antibiotic resistance, and can cause systemic toxicity. Intraosseous regional a...

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Detalhes bibliográficos
Main Authors: Young, Simon W., Zhang, Mei, Freeman, Joshua T., Mutu-Grigg, John, Pavlou, Paul, Moore, Grant A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889447/
https://ncbi.nlm.nih.gov/pubmed/23666589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-013-3038-z
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