PHOSPHODIESTERASE V INHIBITION REDUCES AIRWAY RESPONSIVENESS, BUT DOES NOT IMPROVE THE BENEFICIAL EFFECT OF DEEP INSPIRATION

BACKGROUND: Deep inspirations (DIs) can prevent (bronchoprotection-BP) and reverse (bronchodilation-BD) methacholine (Mch)-induced bronchoconstriction, but this effect is reduced or absent in people with asthma or airways hyperresponsiveness (AHR). The mechanisms of this defect are unknown. OBJECTIV...

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Bibliographic Details
Main Authors: Pyrgos, George, Togias, Alkis, Brown, Robert H.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888955/
https://ncbi.nlm.nih.gov/pubmed/23860331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000350451
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