A Novel Delta Opioid Receptor Antagonist, SoRI-9409, Produces a Selective and Long-Lasting Decrease in Ethanol Consumption in Heavy-Drinking Rats

BACKGROUND: Naltrexone, a compound with high affinity for the μ opioid receptor (MOP-R) reduces alcohol consumption. SoRI-9409 is a derivative of naltrexone that has highest affinity at δ opioid receptors (DOP-Rs). We have investigated the effects of SoRI-9409 on ethanol consumption to determine the...

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Main Authors: Nielsen, Carsten K., Simms, Jeffrey A., Pierson, Haley B., Li, Rui, Saini, Surendra K., Ananthan, Subramaniam, Bartlett, Selena E.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888668/
https://ncbi.nlm.nih.gov/pubmed/18774553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.07.018
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