NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation

Maternal-effect mutations in NLRP7 cause rare biparentally inherited hydatidiform moles (BiHMs), abnormal pregnancies containing hypertrophic vesicular trophoblast but no embryo. BiHM trophoblasts display abnormal DNA methylation patterns affecting maternally methylated germline differentially methy...

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Main Authors: Mahadevan, Sangeetha, Wen, Shu, Wan, Ying-Wooi, Peng, Hsiu-Huei, Otta, Subhendu, Liu, Zhandong, Iacovino, Michelina, Mahen, Elisabeth M., Kyba, Michael, Sadikovic, Bekim, Van den Veyver, Ignatia B.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888260/
https://ncbi.nlm.nih.gov/pubmed/24105472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt457
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