Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator.

We demonstrate here that coexpression of ROMK2, an inwardly rectifying ATP-sensitive renal K+ channel (IKATP) with cystic fibrosis transmembrane regulator (CFTR) significantly enhances the sensitivity of ROMK2 to the sulfonylurea compound glibenclamide. When expressed alone, ROMK2 is relatively inse...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	McNicholas, C M, Guggino, W B, Schwiebert, E M, Hebert, S C, Giebisch, G, Egan, M E
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.8083
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