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Reverse Signaling through the Co-Stimulatory Ligand, CD137L, as a Critical Mediator of Sterile Inflammation

CD137 (also called 4-1BB and TNFRSF9) has recently received attention as a therapeutic target for cancer and a variety of autoimmune and inflammatory diseases. Stimulating CD137 in vivo enhances CD8(+) T cell-activity and results in strong immunosuppression in some contexts. This paradoxical phenome...

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Detalhes bibliográficos
Main Authors: Park, Sang Jun, Kim, Hye Jeong, Lee, Jong Soo, Cho, Hong Rae, Kwon, Byungsuk
Formato: Artigo
Idioma:Inglês
Publicado em: Korea Society for Molecular and Cellular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887753/
https://ncbi.nlm.nih.gov/pubmed/22526397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-012-0077-3
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