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Impaired Autoproteolytic Cleavage of mCLCA6, a Murine Integral Membrane Protein Expressed in Enterocytes, Leads to Cleavage at the Plasma Membrane Instead of the Endoplasmic Reticulum

CLCA proteins (calcium-activated chloride channel regulators) have been linked to diseases involving secretory disorders, including cystic fibrosis (CF) and asthma. They have been shown to modulate endogenous chloride conductance, possibly by acting as metalloproteases. Based on the differential pro...

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Detalhes bibliográficos
Main Authors: Bothe, Melanie K., Mundhenk, Lars, Beck, Carol L., Kaup, Matthias, Gruber, Achim D.
Formato: Artigo
Idioma:Inglês
Publicado em: Korea Society for Molecular and Cellular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887709/
https://ncbi.nlm.nih.gov/pubmed/22350745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-012-2217-1
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