Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated and inactivated glycogen synthase. This versatile protein is involved in numerou...

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Main Authors: McCubrey, J A, Steelman, L S, Bertrand, F E, Davis, N M, Abrams, S L, Montalto, G, D'Assoro, A B, Libra, M, Nicoletti, F, Maestro, R, Basecke, J, Cocco, L, Cervello, M, Martelli, A M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887408/
https://ncbi.nlm.nih.gov/pubmed/23778311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.184
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