Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man

Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional regulators has predominantly come from mouse studies, with rare, naturally occu...

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Autors principals: Flanagan, Sarah E., De Franco, Elisa, Lango Allen, Hana, Zerah, Michele, Abdul-Rasoul, Majedah M., Edge, Julie A., Stewart, Helen, Alamiri, Elham, Hussain, Khalid, Wallis, Sam, de Vries, Liat, Rubio-Cabezas, Oscar, Houghton, Jayne A.L., Edghill, Emma L., Patch, Ann-Marie, Ellard, Sian, Hattersley, Andrew T.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2014
Matèries:
Short Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887257/
https://ncbi.nlm.nih.gov/pubmed/24411943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.021
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