Prion Infection Impairs Cholesterol Metabolism in Neuronal Cells

Conversion of prion protein (PrP(C)) into a pathological isoform (PrP(Sc)) during prion infection occurs in lipid rafts and is dependent on cholesterol. Here, we show that prion infection increases the abundance of cholesterol transporter, ATP-binding cassette transporter type A1 (ATP-binding casset...

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Hlavní autoři: Cui, Huanhuan L., Guo, Belinda, Scicluna, Benjamin, Coleman, Bradley M., Lawson, Victoria A., Ellett, Laura, Meikle, Peter J., Bukrinsky, Michael, Mukhamedova, Nigora, Sviridov, Dmitri, Hill, Andrew F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887205/
https://ncbi.nlm.nih.gov/pubmed/24280226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535807
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