FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of GCTs. GATA4 is abundantly expressed in GCTs and its...

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Bibliographische Detailangaben
Hauptverfasser: Anttonen, Mikko, Pihlajoki, Marjut, Andersson, Noora, Georges, Adrien, L'Hôte, David, Vattulainen, Sanna, Färkkilä, Anniina, Unkila-Kallio, Leila, Veitia, Reiner A., Heikinheimo, Markku
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887065/
https://ncbi.nlm.nih.gov/pubmed/24416423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085545
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