Glucose Regulates Rat Beta Cell Number through Age-Dependent Effects on Beta Cell Survival and Proliferation

BACKGROUND: Glucose effects on beta cell survival and DNA-synthesis suggest a role as regulator of beta cell mass but data on beta cell numbers are lacking. We examined outcome of these influences on the number of beta cells isolated at different growth stages in their population. METHODS: Beta cell...

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Main Authors: Assefa, Zerihun, Lavens, Astrid, Steyaert, Christophe, Stangé, Geert, Martens, Geert A., Ling, Zhidong, Hellemans, Karine, Pipeleers, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887027/
https://ncbi.nlm.nih.gov/pubmed/24416358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085174
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