Toll‐Like Receptor‐2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin‐1β Upregulation via Nuclear Factor κB Activation

BACKGROUND: Inflammation is induced in the heart during the development of cardiac hypertrophy. The initiating mechanisms and the role of inflammation in cardiac hypertrophy, however, remain unclear. Toll‐like receptor‐2 (TLR2) recognizes endogenous molecules that induce noninfectious inflammation....

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Detalhes bibliográficos
Main Authors: Higashikuni, Yasutomi, Tanaka, Kimie, Kato, Megumi, Nureki, Osamu, Hirata, Yasunobu, Nagai, Ryozo, Komuro, Issei, Sata, Masataka
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886766/
https://ncbi.nlm.nih.gov/pubmed/24249711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000267
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