Toll‐Like Receptor‐2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin‐1β Upregulation via Nuclear Factor κB Activation

BACKGROUND: Inflammation is induced in the heart during the development of cardiac hypertrophy. The initiating mechanisms and the role of inflammation in cardiac hypertrophy, however, remain unclear. Toll‐like receptor‐2 (TLR2) recognizes endogenous molecules that induce noninfectious inflammation....

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Hlavní autoři: Higashikuni, Yasutomi, Tanaka, Kimie, Kato, Megumi, Nureki, Osamu, Hirata, Yasunobu, Nagai, Ryozo, Komuro, Issei, Sata, Masataka
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886766/
https://ncbi.nlm.nih.gov/pubmed/24249711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000267
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