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Defining, Evaluating, and Removing Bias Induced by Linear Imputation in Longitudinal Clinical Trials with MNAR Missing Data

Missing not at random (MNAR) post-dropout missing data from a longitudinal clinical trial result in the collection of “biased data”, which leads to biased estimators and tests of corrupted hypotheses. In a full rank linear model analysis the model equation, E[Y] = Xβ, leads to the definition of the...

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Detalhes bibliográficos
Main Authors: Helms, Ronald W., Helms-Reece, Laura, Helms, Russell W., Helms, Mary W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886340/
https://ncbi.nlm.nih.gov/pubmed/21390998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2011.550097
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