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Hypothiocyanous acid oxidation of tubulin cysteines inhibits microtubule polymerization

Thiol oxidation is a probable outcome of cellular oxidative stress and is linked to degenerative disease progression. In addition, protein thiol redox reactions are increasingly identified as a mechanism to regulate protein structure and function. We assessed the effect of hypothiocyanous acid on th...

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Detalhes bibliográficos
Main Authors: Clark, Hillary M., Hagedorn, Tara D., Landino, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885989/
https://ncbi.nlm.nih.gov/pubmed/24215946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2013.10.026
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