Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: The Jackson Heart Study

BACKGROUND: African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium chann...

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Main Authors: Akylbekova, Ermeg L., Payne, John P., Newton-Cheh, Christopher, May, Warren L., Fox, Ervin R., Wilson, James G., Sarpong, Daniel F., Taylor, Herman A., Maher, Joseph F.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884587/
https://ncbi.nlm.nih.gov/pubmed/24332150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ahj.2013.10.009
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