An APOA5 3′ UTR Variant Associated with Plasma Triglycerides Triggers APOA5 Downregulation by Creating a Functional miR-485-5p Binding Site

APOA5 c.(∗)158C>T (rs2266788), located in the 3′ UTR, belongs to APOA5 haplotype 2 (APOA5(∗)2), which is strongly associated with plasma triglyceride levels and modulates the occurrence of both moderate and severe hypertriglyceridemia. Individuals with APOA5(∗)2 display reduced APOA5 expression a...

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Detalhes bibliográficos
Main Authors: Caussy, Cyrielle, Charrière, Sybil, Marçais, Christophe, Di Filippo, Mathilde, Sassolas, Agnès, Delay, Mireille, Euthine, Vanessa, Jalabert, Audrey, Lefai, Etienne, Rome, Sophie, Moulin, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882731/
https://ncbi.nlm.nih.gov/pubmed/24387992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.12.001
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