Local Partition Coefficients Govern Solute Permeability of Cholesterol-Containing Membranes

The permeability of lipid membranes for metabolic molecules or drugs is routinely estimated from the solute’s oil/water partition coefficient. However, the molecular determinants that modulate the permeability in different lipid compositions have remained unclear. Here, we combine scanning electroch...

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Bibliographic Details
Main Authors: Zocher, Florian, van der Spoel, David, Pohl, Peter, Hub, Jochen S.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2013
Subjects:
Membrane
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882504/
https://ncbi.nlm.nih.gov/pubmed/24359748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.003
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