A(1) adenosine receptor negatively modulates coronary reactive hyperemia via counteracting A(2A)-mediated H(2)O(2) production and K(ATP) opening in isolated mouse hearts

We previously demonstrated that A(2A), but not A(2B), adenosine receptors (ARs) mediate coronary reactive hyperemia (RH), possibly by producing H(2)O(2) and, subsequently, opening ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle cells. In this study, A(1) AR knockout (KO), A(3) AR KO,...

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Detalhes bibliográficos
Main Authors: Zhou, Xueping, Teng, Bunyen, Tilley, Stephen, Mustafa, S. Jamal
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882462/
https://ncbi.nlm.nih.gov/pubmed/24043252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00495.2013
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