Accumulation of 5-Oxoproline in Mouse Tissues After Inhibition of 5-Oxoprolinase and Administration of Amino Acids: Evidence for Function of the γ-Glutamyl Cycle

5-Oxoprolinase catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to L-glutamate with concomitant stoichiometric cleavage of ATP to ADP and inorganic orthophosphate. In this reaction, a step in the γ-glutamyl cycle, 5-oxoproline (formed by the action of γ-gl...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Van Der Werf, Paul, Stephani, Ralph A., Meister, Alton
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1974
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388154/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4151516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.4.1026
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