Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice

Objective. Previous research suggests that acetylcholinesterase (AChE) may be involved in ALS pathogenesis. AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-...

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Auteurs principaux: Marc, Gotkine, Leah, Rozenstein, Ofira, Einstein, Oded, Abramsky, Zohar, Argov, Hanna, Rosenmann
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881454/
https://ncbi.nlm.nih.gov/pubmed/24455732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/845345
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