Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice

Objective. Previous research suggests that acetylcholinesterase (AChE) may be involved in ALS pathogenesis. AChE enzyme inhibitors can upregulate AChE transcription which in certain contexts can have deleterious (noncatalytic) effects, making them theoretically harmful in ALS, whilst AChE antisense-...

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Detalhes bibliográficos
Main Authors: Marc, Gotkine, Leah, Rozenstein, Ofira, Einstein, Oded, Abramsky, Zohar, Argov, Hanna, Rosenmann
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881454/
https://ncbi.nlm.nih.gov/pubmed/24455732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/845345
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