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N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death

A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and ind...

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Detalhes bibliográficos
Main Authors: Zheng, Jie, Lou, Jessica R., Zhang, Xiao-Xi, Benbrook, Doris M., Hanigan, Marie H., Lind, Stuart E., Ding, Wei-Qun
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881362/
https://ncbi.nlm.nih.gov/pubmed/20667650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.07.003
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