Role of RNA in Induction of Hepatic Microsomal Mixed Function Oxidases

Induction of hepatic microsomal cytochrome P-450 and ethylmorphine N-demethylase activity by phenobarbital requires de novo synthesis of mRNA. Inhibition of RNA synthesis by α-amanitin given up to 8 hr after phenobarbital administration substantially inhibits this induction. However, beyond 8 hr aft...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Jacob, Samson T., Scharf, Martin B., Vessel, Elliot S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1974
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4522784/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.3.704
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