Development and Binding Mode Assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid (BGC 945), a Novel Thymidylate Synthase Inhibitor that Targets Tumor Cells

N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid 1 (BGC 945, now known as ONX 0801), is a small molecule thymidylate synthase (TS) inhibitor discovered at the Institute of Cancer Research in London. It is...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tochowicz, Anna, Dalziel, Sean, Eidam, Oliv, O’Connell, Joseph D., Griner, Sarah, Finer-Moore, Janet S., Stroud, Robert M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880649/
https://ncbi.nlm.nih.gov/pubmed/23710599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400490e
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