Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

Type I (alpha, beta) and type II (gamma) interferons (IFNs) can restrict the growth of many cell types. INF-stimulated gene transcription, a key early event in IFN response, acts through the Janus kinase-signal transducers and activators of transcription pathway, in which both IFN-alpha and IFN-gamm...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bromberg, J F, Horvath, C M, Wen, Z, Schreiber, R D, Darnell, J E
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC38805/
https://ncbi.nlm.nih.gov/pubmed/8755534
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