Silymarin Induces Insulin Resistance through an Increase of Phosphatase and Tensin Homolog in Wistar Rats

BACKGROUND AND AIMS: Phosphatase and tensin homolog (PTEN) is a phosphoinositide phosphatase that regulates crucial cellular functions, including insulin signaling, lipid and glucose metabolism, as well as survival and apoptosis. Silymarin is the active ingredient in milk thistle and exerts numerous...

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Main Authors: Cheng, Kai-Chun, Asakawa, Akihiro, Li, Ying-Xiao, Chung, Hsien-Hui, Amitani, Haruka, Ueki, Takatoshi, Cheng, Juei-Tang, Inui, Akio
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880317/
https://ncbi.nlm.nih.gov/pubmed/24404172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084550
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