UGT1A1 Genotype-guided Phase I Study of Irinotecan, Oxaliplatin, and Capecitabine

PURPOSE: We performed a UGT1A1 genotype-guided study to determine the maximum tolerated dose (MTD) and evaluate the toxicities and pharmacokinetics of the combination of capecitabine (CAP), oxaliplatin (OX), and irinotecan (IRIN). EXPERIMENTAL DESIGN: Patients were screened for UGT1A1 *28 genotype p...

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Main Authors: Goetz, Matthew P., McKean, Heidi A., Reid, Joel M, Mandrekar, Sumithra J., Tan, Angelina D., Kuffel, Mary A., Safgren, Stephanie L., McGovern, Renee M., Goldberg, Richard M., Grothey, Axel A., McWilliams, Robert, Erlichman, Charles, Ames, Matthew M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880122/
https://ncbi.nlm.nih.gov/pubmed/24114122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-0034-9
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