Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

Signal transducer and activator of transcription 3 (STAT3) is an oncogene and immune checkpoint commonly activated in cancer cells and in tumor-associated immune cells. We previously developed an immunostimulatory strategy based on targeted Stat3 silencing in Toll-like receptor 9 (TLR9)-positive hem...

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Detalhes bibliográficos
Main Authors: Hossain, Dewan Md Sakib, Dos Santos, Cedric, Zhang, Qifang, Kozlowska, Anna, Liu, Hongjun, Gao, Chan, Moreira, Dayson, Swiderski, Piotr, Jozwiak, Agnieszka, Kline, Justin, Forman, Stephen, Bhatia, Ravi, Kuo, Ya-Huei, Kortylewski, Marcin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879904/
https://ncbi.nlm.nih.gov/pubmed/24169824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-517987
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