Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy

We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and...

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Detalhes bibliográficos
Main Authors: Eapen, Mary, Klein, John P., Ruggeri, Annalisa, Spellman, Stephen, Lee, Stephanie J., Anasetti, Claudio, Arcese, William, Barker, Juliet N., Baxter-Lowe, Lee Ann, Brown, Maria, Fernandez-Vina, Marcelo A., Freeman, John, He, Wensheng, Iori, Anna Paola, Horowitz, Mary M., Locatelli, Franco, Marino, Susana, Maiers, Martin, Michel, Gerard, Sanz, Guillermo F., Gluckman, Eliane, Rocha, Vanderson
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879902/
https://ncbi.nlm.nih.gov/pubmed/24141369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-506253
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