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Shared Genomic Segment Analysis: The Power to Find Rare Disease Variants

Shared genomic segment (SGS) analysis is a method that uses dense SNP genotyping in high-risk pedigrees to identify regions of sharing between cases. Here, we illustrate the power of SGS to identify dominant rare risk variants. Using simulated pedigrees, we consider 12 disease models based on diseas...

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Bibliografiska uppgifter
Huvudupphovsmän:	Knight, Stacey, Abo, Ryan P, Abel, Haley J, Neklason, Deborah W, Tuohy, Therese M, Burt, Randall W, Thomas, Alun, Camp, Nicola J
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	2012
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3879794/ https://ncbi.nlm.nih.gov/pubmed/22989048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-1809.2012.00728.x
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Shared Genomic Segment Analysis: The Power to Find Rare Disease Variants

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