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Interferon Induction by Synthetic Polynucleotides: Importance of Purine N-7 and Strandwise Rearrangement

The antiviral activity and interferon-inducing ability of single-, double-, and triple-stranded polynucleotides, modified at pyrimidine C-5 or purine N-7, were evaluated in primary rabbit kidney cells challenged with vesicular stomatitis virus. (1) There is a parallel increase in antiviral activity...

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Hlavní autoři: Clercq, Erik de, Torrence, Paul F., Witkop, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: 1974
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC387961/
https://ncbi.nlm.nih.gov/pubmed/4359328
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