Hydrogen Peroxide Regulates Osteopontin Expression through Activation of Transcriptional and Translational Pathways

Recent in vivo studies establish that osteopontin (OPN) expression is hydrogen peroxide (H(2)O(2))-dependent. However, the mechanisms by which H(2)O(2) increases OPN expression remain poorly defined. OPN protein expression increased in an unusual biphasic pattern in response to H(2)O(2). To investig...

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Autori principali: Lyle, Alicia N., Remus, Ebony W., Fan, Aaron E., Lassègue, Bernard, Walter, Grant A., Kiyosue, Arihiro, Griendling, Kathy K., Taylor, W. Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879550/
https://ncbi.nlm.nih.gov/pubmed/24247243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489641
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