Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

During infection and tissue damage, virulence factors and alarmins are pro-inflammatory and induce activation of various immune cells including macrophages and mast cells (MCs). Activated MCs instantly release preformed inflammatory mediators, including several proteases. The chymase mouse mast cell...

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Autori principali: Roy, Ananya, Ganesh, Goutham, Sippola, Helena, Bolin, Sara, Sawesi, Osama, Dagälv, Anders, Schlenner, Susan M., Feyerabend, Thorsten, Rodewald, Hans-Reimer, Kjellén, Lena, Hellman, Lars, Åbrink, Magnus
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879547/
https://ncbi.nlm.nih.gov/pubmed/24257755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.435156
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