Germ Line Basis for Antibody Diversity: Immunoglobulin V(H)- and C(H)-gene Frequencies Measured by DNA·RNA Hybridization
The reiteration frequency for mouse immunoglobulin V(H)-genes and C(H)-genes has been directly estimated by hybridization of purified MOPC 315 α-chain mRNA with a vast excess of mouse DNA. A biphasic C(o)t curve resulted. The low C(o)t transition (C(o)t(1/2) about 1.5) was interpreted as hybridizati...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1974
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387941/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4521059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.1.99 |
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