Systemic Simvastatin Rescues Retinal Ganglion Cells from Optic Nerve Injury Possibly through Suppression of Astroglial NF-κB Activation

Neuroinflammation is involved in the death of retinal ganglion cells (RGCs) after optic nerve injury. The purpose of this study was to determine whether systemic simvastatin can suppress neuroinflammation in the optic nerve and rescue RGCs after the optic nerve is crushed. Simvastatin or its vehicle...

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Detalhes bibliográficos
Main Authors: Morishita, Seita, Oku, Hidehiro, Horie, Taeko, Tonari, Masahiro, Kida, Teruyo, Okubo, Akiko, Sugiyama, Tetsuya, Takai, Shinji, Hara, Hideaki, Ikeda, Tsunehiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879303/
https://ncbi.nlm.nih.gov/pubmed/24392131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084387
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