Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases from Human Chondrocytes Requires Mitogen-Activated Protein Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathways

Elevations in matrix metalloproteinase 1 (MMP-1) and MMP-3 have been found in patients with Lyme arthritis and in in vitro models of Lyme arthritis using cartilage explants and chondrocytes. The pathways by which B. burgdorferi, the causative agent of Lyme disease, induces the production of MMP-1 an...

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Autors principals: Behera, Aruna K., Thorpe, Cheleste M., Kidder, J. Michael, Smith, Wendy, Hildebrand, Ethan, Hu, Linden T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC387916/
https://ncbi.nlm.nih.gov/pubmed/15102798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.2864-2871.2004
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