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Macropinocytosis is the Major Pathway Responsible for DNA Transfection in CHO cells by a Charge-Reversal Amphiphile

The cellular uptake of a functional charge-reversal amphiphile:DNA lipoplex is described. First, pharmacological inhibitors were applied to block different endocytosis pathways. By examining the resulting transfection activities, it was found that endocytosis was the pathway leading to transfection...

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Detalhes bibliográficos
Main Authors: Zhang, Xiao-Xiang, Allen, Phillip G., Grinstaff, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878857/
https://ncbi.nlm.nih.gov/pubmed/21449536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100366h
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