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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity
Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca(2+)-dependent phosphatidylserine exposure and is defective in patients with Scott syndrome, a rare bleeding disorder. Ano6 may also...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3877565/ https://ncbi.nlm.nih.gov/pubmed/24357800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.495 |
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