Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation

HOXA9 expression is a common feature of acute myeloid leukemia, and high-level expression is correlated with poor prognosis. Moreover, HOXA9 overexpression immortalizes murine marrow progenitors that are arrested at a promyelocytic stage of differentiation when cultured and causes leukemia in recipi...

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Main Authors: Vijapurkar, Ulka, Fischbach, Neal, Shen, Weifang, Brandts, Christian, Stokoe, David, Lawrence, H. Jeffrey, Largman, Corey
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC387750/
https://ncbi.nlm.nih.gov/pubmed/15082777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3827-3837.2004
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