Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1

LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally essential receptor with roles in cargo transport and cellular signaling. Somatic LRP1b mutations frequently...

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Bibliographic Details
Main Authors: Marschang, Peter, Brich, Jochen, Weeber, Edwin J., Sweatt, J. David, Shelton, John M., Richardson, James A., Hammer, Robert E., Herz, Joachim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC387731/
https://ncbi.nlm.nih.gov/pubmed/15082773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.3782-3793.2004
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