Use of engineered ribozymes to catalyze chimeric gene assembly.
We report the use of engineered ribozymes to shuffle exon cassettes in vitro. Specifically, we have designed derivatives of a group II intron that insert into selected sites in the human tissue plasminogen activator (t-PA) mRNA. The insertion reaction links t-PA sequences to the group II intron sequ...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8755500/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.15.7486 |
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